Synthesis and structures of malonate derivative-calix[4]arene conjugates

A series of malonate derivatives-calix[4]arene conjugates were synthesized through Knoevenagel condensation reaction between formyl-tetrapropoxycalix[4]arene and malonate derivatives. The structures of the resulting malonate derivative functionalized calix[4]arenes were characterized by NMR spectroscopy, mass spectrometry and even single crystal X-ray diffraction analysis.

Graphical abstractA series of novel malonate derivatives-calix[4]arene conjugates were synthesized through Knoevenagel condensation reaction, and the structures of these functionalized calix[4]arenes have been determined.Figure optionsDownload full-size imageDownload as PowerPoint slide