| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1256852 | Chinese Chemical Letters | 2015 | 4 Pages |
Abstract
Aminopeptidase N (APN) is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe (Bes-Green, 2) that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells (ES-2) and has potential application in biological study of cellular APN.
Graphical abstractIn this article, a bestatin-based fluorescent probe has been well designed and synthesized for APN cellular imaging.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Hui Chen, Hui Wang, Xiao-Jun Qin, Chen Chen, Lu Feng, Lai-Zhong Chen, Lu-Pei Du, Min-Yong Li,