Highly efficient and regioselective thiocyanation of aromatic amines, anisols and activated phenols with H2O2/NH4SCN catalyzed by nanomagnetic Fe3O4

A new method employing magnetic nanoparticles Fe3O4 as a catalyst and H2O2 as a green oxidant is developed for the oxidative thiocyanation of aromatic amines, anisols and activated phenols with high yields under mild reaction conditions. The catalyst could be easily recovered from the reaction mixture using an external magnet and reused in several reaction cycles without loss of activity.

Graphical abstractA new method employing magnetic nanoparticles Fe3O4 as a catalyst and H2O2 as a green oxidant is developed for the oxidative thiocyanation of aromatic amines, anisols and activated phenols with high yields under mild reaction conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide