Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

A series of indazol-2-yl(pyridin-4-yl)methanones, 4 were acquired from 2,6-bisbenzylidene cyclohexanones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g–j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs (streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL).

Graphical abstractA series of indazol-2-yl(pyridin-4-yl)methanones were synthesized. The compounds 4g–j showed moderate anti-tubercular activity with MIC 12.5 μg/mL comparable to standard drugs.Figure optionsDownload full-size imageDownload as PowerPoint slide