Three-component reaction for synthesis of functionalized spiro[indoline-3,4′-pyrano[3,2-h]quinolines]

The functionalized spiro[indoline-3,4′-pyrano[3,2-h]quinolines] were efficiently prepared in high yields from three-component reaction of 8-hydroxyquinoline, isatins and malononitrile or ethyl cyanoacetate in ethanol at room temperature for about 12 h in the presence of piperidine.

Graphical abstractThe functionalized spiro[indoline-3,4′-pyrano[3,2-h]quinolines] were efficiently prepared in high yields from three-component reaction of 8-hydroxyquinoline, isatins and malononitrile or ethyl cyanoacetate in ethanol at room temperature for about 12 h in the presence of piperidine.Figure optionsDownload full-size imageDownload as PowerPoint slide