Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation

A series of novel thiazolidinedione–triazole hybrids were synthesized by one pot reaction between thiazolidine-2,4-dione, substituted aryl aldehydes, propargyl bromide and substituted aryl azides using piperidine, CuSO4·5H2O and sodium ascorbate as catalysts in PEG-400 as a highly efficient and green media. These thiazolidinedione–triazole hybrids were subjected to in vitro antibacterial activity against four strains namely, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against two fungal strains namely, Aspergillus niger and Aspergillus flavus.

Graphical abstractA series of novel thiazolidinedione–triazole hybrids have been synthesized by one-pot reaction and were further evaluated for their antimicrobial screening.Figure optionsDownload full-size imageDownload as PowerPoint slide