Facile synthesis of phthalan derivatives via a Pd-catalyzed tandem hydroalkynylation, isomerization, Diels–Alder cycloaddition and aromatization reaction

A novel Pd-catalyzed tandem reaction involving hydroalkynylation, isomerization, Diels–Alder cycloaddition and aromatization reaction to produce phthalan derivatives in moderate yields is reported. The reaction is atom economical and occurs in a highly ordered fashion. The reaction mechanism is discussed.

Graphical abstractA novel Pd-catalyzed tandem reaction involving hydroalkynylation, isomerization, Diels–Alder cycloaddition and aromatization reaction to produce phthalan derivatives in moderate yields is reported. The reaction is atom economical and occurs in a highly ordered fashion and the reaction mechanism is also discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide