Article ID Journal Published Year Pages File Type
1256976 Chinese Chemical Letters 2015 4 Pages PDF
Abstract

A novel and efficient method for the preparation of nucleoside 5′-tetraphosphates has been developed by coupling nucleoside 5′-phosphoropiperidates with triphosphate reagent in the presence of 4,5-dicyanoimidazole (DCI) activator. Further coupling of the nucleoside 5′-tetraphosphates with nucleoside 5′-phosphoropiperidates via the P(V)N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.

Graphical abstractThe P(V)N activation methods for the synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates have been developed.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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