Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1256976 | Chinese Chemical Letters | 2015 | 4 Pages |
Abstract
A novel and efficient method for the preparation of nucleoside 5′-tetraphosphates has been developed by coupling nucleoside 5′-phosphoropiperidates with triphosphate reagent in the presence of 4,5-dicyanoimidazole (DCI) activator. Further coupling of the nucleoside 5′-tetraphosphates with nucleoside 5′-phosphoropiperidates via the P(V)N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.
Graphical abstractThe P(V)N activation methods for the synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates have been developed.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Qi Sun, Jian Sun, Shan-Shan Gong, Cheng-Jun Wang, Xing-Cong Wang,