Article ID Journal Published Year Pages File Type
1256979 Chinese Chemical Letters 2015 5 Pages PDF
Abstract

A facile synthesis of suvorexant, an orexin receptor antagonist, is described. The key intermediate 6 was prepared from R-3-aminobutyric acid through protection, condensation, deprotection, cyclization, and hydrogenation steps. The title product was obtained with a total yield of 31% (>99% ee) after eight linear steps using commercially available raw materials.

Graphical abstractSuvorexant was obtained with a total yield of 31% after eight linear steps using commercially available R-3-aminobutyric acid.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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