Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1256979 | Chinese Chemical Letters | 2015 | 5 Pages |
Abstract
A facile synthesis of suvorexant, an orexin receptor antagonist, is described. The key intermediate 6 was prepared from R-3-aminobutyric acid through protection, condensation, deprotection, cyclization, and hydrogenation steps. The title product was obtained with a total yield of 31% (>99% ee) after eight linear steps using commercially available raw materials.
Graphical abstractSuvorexant was obtained with a total yield of 31% after eight linear steps using commercially available R-3-aminobutyric acid.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Yin Chen, Yan Zhou, Jun-Hong Li, Jia-Quan Sun, Gui-Sen Zhang,