| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1257091 | Chinese Chemical Letters | 2015 | 5 Pages |
Abstract
A novel copper-catalyzed dual oxidative benzylic CH aminations of methylarenes with 2-aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect (KIE) indicated that CH bond cleavage was the rate-determining step.
Graphical abstractA novel copper-catalyzed dual oxidative benzylic CH aminations of methylarenes with 2-aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Li-Yan Liu, Yi-Zhe Yan, Ya-Jie Bao, Zhi-Yong Wang,