| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1257095 | Chinese Chemical Letters | 2015 | 5 Pages |
A palladium-catalyzed ortho-selective CH bond chlorination reaction for the preparation of 2-chloro aromatic ketones was described. Both electron-withdrawing and electron-donating groups on the aromatic rings are well tolerated under the optimized conditions. The 2-chloro aromatic ketones obtained by our method could be applied to synthesize the derivatives of 1H-indazole or benzo[d]isoxazole.
Graphical abstractA palladium-catalyzed ortho-selective CH bond chlorination reaction for the preparation of 2-chloro aromatic ketones was described. Both electron-withdrawing and electron-donating groups on the aromatic rings are well tolerated under the optimized conditions. The 2-chloro aromatic ketones obtained by our method could be applied to synthesize the derivatives of 1H-indazole or benzo[d]isoxazole.Figure optionsDownload full-size imageDownload as PowerPoint slide
