A cesium fluoride promoted efficient and rapid multicomponent synthesis of functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives

A rapid, one-pot and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using commercially available CsF as a catalyst in the reaction of malononitrile and aryl aldehydes or isatins with 1,3-cyclohexanediones. The major advantages of this methodology are excellent yield at ambient temperature, very short reaction time (5–10 min), and use of an inexpensive catalyst.

Graphical abstractA rapid, one-pot and highly efficient protocol for the synthesis of functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using cesium fluoride (CsF).Figure optionsDownload full-size imageDownload as PowerPoint slide