CeCl3·7H2O-SiO2: Catalyst promoted microwave assisted neat synthesis, antifungal and antioxidant activities of α-diaminophosphonates

CeCl3·7H2O supported on silica (CeCl3·7H2O-SiO2) is used as a heterogeneous, efficient and recyclable catalyst for a three component one-pot reaction of an amine, aldehydes and diethyl phosphite to synthesize α-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions. Ten α-diaminophosphonates (6a–j) of 4,4′-sulfonyldianiline (Dapsone) (3) were synthesized and structural elucidation was confirmed by spectral data. Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC50 values, respectively of the titled compounds. Compounds 6h, 6i exhibited promising antioxidant activity at lower IC50 values 53.7 μg/mL, 53.2 μg/mL, respectively as compared with standard IC50 value 51.6 μg/mL.

Graphical abstractCeCl3·7H2O-SiO2 is an efficient and recyclable catalyst for a three component one-pot reaction of an amine, aldehydes and diethyl phosphite to synthesize α-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide