Synthesis and bio-evaluation of phenothiazine derivatives as new anti-tuberculosis agents

Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents.

Graphical abstractTwo series of phenothiazine derivatives were designed and synthesized. They were evaluated for anti-tuberculosis activity.Figure optionsDownload full-size imageDownload as PowerPoint slide