Solvent free synthesis of trifluoromethyl tertiary alcohols by cross Aldol reaction

Exceedingly fast preparation of trifluoromethyl tertiary alcohols has been accomplished from methyl ketones and trifluoromethyl ketones under solvent free conditions by cross Aldol reaction. The reaction was achieved in the presence of common inorganic base by grinding method at ambient temperature to give β-trifluoromethyl-β-hydroxyl ketones in high yields (up to 95%).

Graphical abstractExceedingly fast preparation of β-trifluoromethyl-β-hydroxyl ketones has been accomplished by cross Aldol reaction from methyl ketones and trifluoromethyl ketones under solvent free conditions in high yields (up to 95%).Figure optionsDownload full-size imageDownload as PowerPoint slide