Synthesis of symmetrical 1,3-diynes via tandem reaction of (Z)-arylvinyl bromides in the presence of DBU and CuI

Microwave-assisted tandem reaction of (Z)-arylvinyl bromides involving an elimination and homocoupling in the presence of DBU and CuI in DMF affords a variety of symmetrical 1,3-diynes in good to excellent yields. This tandem process, eliminating the need of volatile and savory terminal alkynes, provides an alternative to the conventional homocoupling methods for the synthesis of symmetrical 1,3-diynes.

Graphical abstractSynthesis of symmetrical 1,3-diynes from (Z)-arylvinyl bromides.Figure optionsDownload full-size imageDownload as PowerPoint slide