Synthesis of new type of Betti bases via three-component reaction of β-naphthol, cyclic amines and isatins

This work provided the first example of incorporating the oxindole moiety into the Betti bases. The new type of Betti bases were conveniently synthesized in good yields from the three-component reaction of β-naphthol, isatins and cyclic amines, such as piperidine or morpholine, in methylene dichloride without any other catalyst.

Graphical abstractThree-component reaction of β-naphthol, isatins and cyclic amines, such as piperidine or morpholine, in methylene dichloride without any other catalyst afforded new type of Betti bases in good yields.Figure optionsDownload full-size imageDownload as PowerPoint slide