l-Proline catalyzed one-pot multi-component synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)quinazolin-4(3H)-one derivatives and their biological studies

A new series of quinazolin-4(3H)-one derivatives containing a (1,3-diphenyl-1H-pyrazol-4-yl) core with substituents at the 2-position and aromatic or heteroaromatic substituents at the 3-position were synthesized using an l-proline catalyzed one-pot multi-component reaction approach. All the synthesized compounds were characterized and screened for their antimicrobial, antifungal and anti-tubercular activities.

Graphical abstractl-Proline was used as a catalyst in a one-pot multi-component reaction. The reaction provided a facile path for the synthesis of 2,3-disubstituted quinazolinone-4(3H)-ones in good yields.Figure optionsDownload full-size imageDownload as PowerPoint slide