Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257456 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
Asymmetric reduction of α-hydroxy aromatic ketones was carried out by using carrot enzymes system, yielding corresponding chiral vicinal diols with special functional groups. The optimum reaction conditions were obtained after investigation of various influencing factors. Chiral aryl vicinal diols were produced with good yields and excellent enantiomeric excesses under appropriate conditions. Meanwhile, the steric factors and electronic effects of the substituents on the aromatic ring were shown to have an interesting influence on both yield and enantioselectivity.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Xiang Liu, Yi Wang, Hai Yan Gao, Jian He Xu,