Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257551 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
A series of novel glyco-gambogic acid (GA) compounds were synthesized and evaluated for their in vitro anti-proliferative activity against human hepatocellular carcinoma (HCC) cells. All compounds showed much better aqueous solubility (0.92–1.89 mg/mL) than GA (0.013 mg/mL), and displayed potent inhibition on HCC cells (IC50: 0.21–12.23 μmol/L) and little affects on non-tumor liver cells (IC50: 42.56–86.43 μmol/L), suggesting that glyco-GA compounds selectively inhibit HCC proliferation, and may be promising candidates for further intensive study.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Li Qin He, Zhong Hu, La Mei Yuan, Xiao Shan Wang, Yi Hua Zhang,