| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1257586 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
A series of novel mono (2, 2, 2-trifluoroethyl) esters, mono l-amino acid ester prodrugs of acyclic nucleoside phosphonates was synthesized and their in vitro anti-HBVactivity was evaluated in HepG 2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil and alamifovir (MCC-478) with EC50 and CC50 values of 0.01 μmol/L and >8000 μmol/L respectively.
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Authors
Xiao Zhong Fu, Yu Ou, Jan Xin, Yu She Yang,