Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257649 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner–Wadsworth–Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
Keywords
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Jian Gao, Yang Hui Guo, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang,