Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257663 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors, with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step. The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test (OGTT), and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.
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Authors
Wen Jing Zhao, Yong Heng Shi, Gui Long Zhao, Yu Li Wang, Hua Shao, Li Da Tang, Jian Wu Wang,