Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257697 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
Apolipoprotein B100 (apoB-100) is a major protein of the cholesterol-rich low-density lipoprotein (LDL) and reflects a better assessment of total atherogenic burden to the vascular system than LDL. In this work, a simple and sensitive method has been developed to determine picoliter apoB-100s using the PMMA microfluidic chip coupled with electrochemical detection system. This method performs very well with a detectable linear range of 1–800 pg/mL and a detection limit of 1 pg/mL. A real serum sample has further been detected by this microchip-based biosensor. The results show that this kind of method is practicable and has the potential application in clinical analysis and diagnosis.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Cheng Cheng Liu, Yun Liu, Hui Xiang Wang, Yan Bo Qi, Peng Yuan Yang, Bao Hong Liu,