Article ID Journal Published Year Pages File Type
1257751 Chinese Chemical Letters 2010 4 Pages PDF
Abstract

Dihydrotetrabenazine (DTBZ) is the major pharmacologically active form of tetrabenazine (TBZ), which was approved by FDA for the treatment of chorea associated with Huntington's disease (HD). An unexpected Hoffmann elimination was observed during the treatment of DTBZ with sodium hydrogen and alkyl halides, leading to the formation of both eliminated products (major) and hydroxyl-alkylated products (minor).

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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