Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257751 | Chinese Chemical Letters | 2010 | 4 Pages |
Abstract
Dihydrotetrabenazine (DTBZ) is the major pharmacologically active form of tetrabenazine (TBZ), which was approved by FDA for the treatment of chorea associated with Huntington's disease (HD). An unexpected Hoffmann elimination was observed during the treatment of DTBZ with sodium hydrogen and alkyl halides, leading to the formation of both eliminated products (major) and hydroxyl-alkylated products (minor).
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Zhang Yu Yao, Hao Zhang, Huan Ming Sheng, Xiao Ming Wu, Hong Bin Sun,