Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257831 | Chinese Chemical Letters | 2010 | 4 Pages |
Abstract
In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4′-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10−7 mol/L level.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Wen Li Xi, Qian Cai, Yan Bo Tang, Hua Sun, Zhi Yan Xiao,