Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1257869 | Chinese Chemical Letters | 2011 | 4 Pages |
Abstract
Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase II inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells.
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Authors
Fei Deng, Jin Jian Lu, Hong Ying Liu, Li Ping Lin, Jian Ding, Jin Sheng Zhang,