Article ID Journal Published Year Pages File Type
1257869 Chinese Chemical Letters 2011 4 Pages PDF
Abstract
Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase II inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells.
Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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