Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1258034 | Chinese Chemical Letters | 2010 | 4 Pages |
Abstract
In this study, six thiourea derivatives of cinchona alkaloids with 9-nat or 9-epi-configuration were synthesized. After characterized the structures, we adopted them to the asymmetric “interrupted” Feist-Bénary (IFB) reaction of α-haloketones with β-dicarbonyl compounds, to give optically active dihydrofurans. Various thiourea derivatives as organocatalysts were examined. The corresponding chiral hydroxyl dihydrofurans have been obtained in excellent yields and moderate ees. To the acyclic substrate, we obtained exciting and promising result.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Hui Chen, Ru Jiang, Qiao Feng Wang, Xiao Li Sun, Jing Luo, Sheng Yong Zhang,