Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-trimethoxy dihydroflavonols

Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols (3–6) and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols (7–8) were designed and synthesized. Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O2− free radicals, as well as by measuring their inhibitory ability against LPO. Both the 2,3-trans and the 2,3-cis conformers exhibited certain quenching abilities to DPPH and O2− radicals, while most of the synthetic dihydroflavonols demonstrated remarkable inhibition to LPO.