Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1258118 | Chinese Chemical Letters | 2010 | 5 Pages |
Abstract
Microbial transformation of diosgenin (1) by Syncephalastrum racemosum yielded five new polar metabolites, which were identified as (25R)-spirost-5-en-3β,7α,9α-triol-12-one (2), (25R)-spirost-5-en-3β,9α,12α-triol-7-one (3), (25R)-spirost-5-en-3β,9α-diol-7,12-dione(4), (25R)-spirost-4-en-9α,12β,14α-triol-3-one(5), and (25S)-spirost-4-en-9α,14α,25β-triol-3-one (6). Compounds 1–6 exhibited moderate cytotoxicity against K562 cells and among them compounds 2, 3, and 6 were more potent than the parent compound 1.
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Authors
Ying Zhao, Ling Mei Sun, Xiao Ning Wang, Tao Shen, Mei Ji, Xia Li, Hong Xiang Lou,