Article ID Journal Published Year Pages File Type
1258188 Chinese Chemical Letters 2009 4 Pages PDF
Abstract
The activities of the catalytic hydrolysis of phosphate diester (BNPP) [bis(p-nitrophenyl)phosphate diester] and plasmid DNA (pUC18) by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with 1e-Zn(II) complex (composed of lipophilic group) as catalyst. The hydrolysis rate enhancement is up to 3.64 × 104 fold. These metal complexes could effectively promote the cleavage of plasmid DNA (pUC18) at physiological conditions.
Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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