| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1258188 | Chinese Chemical Letters | 2009 | 4 Pages |
Abstract
The activities of the catalytic hydrolysis of phosphate diester (BNPP) [bis(p-nitrophenyl)phosphate diester] and plasmid DNA (pUC18) by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with 1e-Zn(II) complex (composed of lipophilic group) as catalyst. The hydrolysis rate enhancement is up to 3.64Â ÃÂ 104 fold. These metal complexes could effectively promote the cleavage of plasmid DNA (pUC18) at physiological conditions.
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Chemistry
Chemistry (General)
Authors
Qing Xiang Xiang, Li Qun Zhang, Xiao Qi Yu, Ru Gang Xie,