Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1258244 | Chinese Chemical Letters | 2008 | 4 Pages |
Abstract
Diamidine (A) was identified in our in vitro bio-assay as a possible inhibitor of ketol-acid reductoisomerase (KARI) from the ACD database search based on the known three-dimensional crystal structure of KARI. An investigation on interaction of A on KARI active sites, led to the design and synthesis of 15 novel monoamidines. Some of those showed better biological activity than A on rice KARI (in vitro) and in greenhouse herbicidal tests (in vivo). The structure-biological activity relationship was investigated, which provides valuable information to further study of potential KARI inhibitors.
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Authors
Bao Lei Wang, Yong Hong Li, Jian Guo Wang, Yi Ma, Zheng Ming Li,