Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1258272 | Chinese Chemical Letters | 2008 | 4 Pages |
Abstract
The symmetrical diketone II, which can be synthesized in gram scale using a well established method, was used as a starting material to prepare the 11α-methoxy ketomethylene VI. This is in continuation of our study aiming at the synthesis of multi-hydroxylated cephalostatin analogues, as for example cephalostatin 1 I, a potent anti-tumor natural product. Compound VI underwent chemo- and regioselective hydroboration reaction at only one of Δ14,15 double bonds furnishing compound IX as a major product in a fair yield.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Mansour Nawasreh,