| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1258280 | Chinese Chemical Letters | 2008 | 4 Pages |
Abstract
Eighteen 2′,4′-difluoro-3-(carbamoyl)biphenyl-4-yl benzoates were synthesized from diflunisal in three steps with total yields from 72% to 86%. All compounds were identified by IR, 1H NMR, MS and elemental analysis. The anti-inflammatory activity and analgesic activity for 18 compounds were evaluated. The preliminary assay results showed that compounds 4a and 4p exhibited potent anti-inflammatory-analgesic activity.
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Authors
Guang Xiang Zhong, Lu Lu Chen, Jian Li, Wei Xiao Hu, Min You Qi,