| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1258527 | Chinese Chemical Letters | 2007 | 4 Pages |
Abstract
A series of arylpiperazinesquinazoline-2,4-diamine compounds were designed and synthesized based on pharmacophore for uro-selective α1-adrenoceptor antagonists and 3D chemical database searching. The in vitro functional analysis showed that compounds 9 and 14 showed better and similar α1-AR antagonistic activity compared with prazosin.
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Hao Fang, Min Yong Li, Lin Xia,