| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1258703 | Chinese Chemical Letters | 2007 | 4 Pages |
Abstract
A series of 2-alkylbenzimidazole derivatives 9a-n have been designed and synthesized as a novel class of non-peptide angiotensin II AT1 receptor antagonists. The synthesized compounds were evaluated for their antagonism of angiotensin II, induced contraction in the rabbit thoracic aortic ring and the results showed that compounds 9a, 9g and 9j exhibited potent antagonistic activity of AT1 receptor.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Jin Yi Xu, Qian Ran, Wei Yi Hua, Xiao Ming Wu, Qiu Juan Wang, Jing Zhang,