A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib

A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2′,6′-trihydroxy-3″′, 8-di (γ, γ-dimethyl-allyl)-2″′, 2″′-dimethylpyrano-[5″′,6″′: 6,7]-2″″′,4″″′-cyclohexadiene-1′″″-one-[2′″″,3′″″: 3′,4′]-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells' growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro.