| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1258809 | Chinese Chemical Letters | 2007 | 4 Pages |
Abstract
Some new sulfonylureas and their hydroxylation products had been synthesized from 2-amino-4-methylpyrimidine. Their bioactivities against E. coli AHAS II in vitro were tested and the results indicated that the hydroxylation decreased the inhibition activities of sulfonylureas significantly. Subsequently herbicidal tests against stem-growth of barnyard grass and root-growth of rape confirmed the above conclusion. The preliminary molecular docking studies were also carried out to investigate the binding modes of non-hydroxylated and hydroxylated sulfonylureas with AHAS.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Shu Rong Ban, Cong Wei Niu, Wen Bin Chen, Zhi Hong Yu, Si Wu, Chen Wang, Zhen Xi,