| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368601 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akihiro Ogura, Tsuyoshi Tahara, Satoshi Nozaki, Hirotaka Onoe, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka,