| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369853 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian Pinnigorgia sp. afforded two new sterols, 11-acetoxy-24S-methyl-3β,5α,6α-trihydroxy-9,11-secocholest-7-en-9-one (1) and 5β,6β-epoxy-(22E,24R)-ergosta-8,22-diene-3β,7β-diol (2). The structures of sterols 1 and 2 were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Yin-Di Su, Ching-Hsiao Cheng, Zhi-Hong Wen, Yang-Chang Wu, Ping-Jyun Sung,