| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374008 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A novel sphingomyelin inhibitor RY221B-a, which contains a bipyridyl moiety as a metal coordination site was designed based upon the mechanism of phosphate ester hydrolysis. RY221B-a was synthesized from N-Boc-sphingosine in three steps via selective etherification using stannyl acetal. Synthesized RY221B-a exhibited relatively-strong inhibitory activity against Bc-SMase (IC50 = 1.2 μM).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroshi Imagawa, Masataka Oda, Takayuki Takemoto, Rieko Yamauchi, Tomomi Yoshikawa, Hirofumi Yamamoto, Mugio Nishizawa, Hironobu Takahashi, Manabu Hashimoto, Kenta Yabiku, Masahiro Nagahama, Jun Sakurai,