| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374385 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of 2,5-cis-disubstituted pyrrolidines were synthesized and evaluated as S1P receptor agonists. Compounds 15–21 were identified with good selectivity over S1P3 which lowered circulating lymphocytes after oral administration in mice.
Graphical abstractA series of 2-aryl(pyrrolidine-5-yl)acetic acids (e.g., 21) were synthesized and evaluated as S1P receptor agonists. Compounds 15–21 were identified with good selectivity over S1P3 and found to lower peripheral lymphocytes after oral administration in mice.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vincent J. Colandrea, Irene E. Legiec, Pei Huo, Lin Yan, Jeffrey J. Hale, Sander G. Mills, James Bergstrom, Deborah Card, Gary Chebret, Richard Hajdu, Carol Ann Keohane, James A. Milligan, Mark J. Rosenbach, Gan-Ju Shei, Suzanne M. Mandala,