Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374808 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
A series of new β-carboline derivatives, bearing a benzylidine substituent at position-1, has been prepared and evaluated in vitro against a panel of human cell lines. The N2-benzylated β-carbolinium bromates represented the most interesting cytotoxic activities. In particular, compounds 19 were found to be the most potent compounds with IC50 values lower than 5 μM against 10 strains human tumor cell lines. These results confirmed that the N2-benzyl substituent on the β-carboline ring played an important role in the modulation of the cytotoxic activities and suggested that further development of such compounds may be interest.
Graphical abstractA series of new β-carboline derivatives, bearing a benzylidine substituent at position-1, has been prepared and evaluated in vitro against a panel of human cell lines. The N2-benzylated β-carbolinium bromates represented the most interesting cytotoxic activities. Compounds 19 were found to be the most potent compounds with IC50 values lower than 5 μM against 10 strains human tumor cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide