| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376365 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Exploration for new MDR-modulator utilizing tetrahydroisoquinoline as scaffold disclosed 6,7-dimethoxy-1-(3,4-dimethoxy)benzyl-2-(N-n-octyl-N′-cyano)guanyl-1,2,3,4-tetrahydroisoquinoline (7) as a readily accessible medicinal lead. Compound 7 possessed potent MDR reversal activity in the range of the reference compound verapamil, and had not cardiovascular activity compared to verapamil.
Graphical abstractSynthesis and biological evaluation of potent MDR reversal agent 7 are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yu Li, Hui-bin Zhang, Wen-long Huang, Yun-man Li,