Article ID Journal Published Year Pages File Type
1377438 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

A novel series of conformationally restricted oxazolidinones was synthesized, in which the heterocyclic D ring was substituted with various amino groups. Several analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms. Certain amino-substituted analogs also exhibited improved aqueous solubility compared to the corresponding un-substituted heterocyclic D-ring analogs.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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