Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377438 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A novel series of conformationally restricted oxazolidinones was synthesized, in which the heterocyclic D ring was substituted with various amino groups. Several analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms. Certain amino-substituted analogs also exhibited improved aqueous solubility compared to the corresponding un-substituted heterocyclic D-ring analogs.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Allison L. Choy, J.V.N. Vara Prasad, Frederick E. Boyer, Michael D. Huband, Michael R. Dermyer,