| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377982 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
5-Benzylidene-2-thioxo-thiazolidin-4-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. The identified compounds show micromolar ADAMTS-5 potency and demonstrate SAR trends for both the aryl group and thioxothiazolidinone zinc chelator. This series of compounds represents steps toward a metalloprotease inhibitor as a disease-modifying osteoarthritis drug.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Matthew G. Bursavich, Adam M. Gilbert, Sabrina Lombardi, Katy E. Georgiadis, Erica Reifenberg, Carl R. Flannery, Elisabeth A. Morris,