| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379230 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 μM).
Graphical abstractA series of substituted quinoxalines (29 compounds) was synthesized and evaluated against several protozoa. Some of them showed promising antileishmanial activity against Leishmania donovani.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xu Hui, Julie Desrivot, Christian Bories, Philippe M. Loiseau, Xavier Franck, Reynald Hocquemiller, Bruno Figadère,