| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379278 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis and structure–activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay.
Graphical abstractThe synthesis and SAR for a new class of centrally active NK-1 receptor antagonists are described. The new compounds all have a piperazinyl oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adri van den Hoogenband, Jan H. van Maarseveen, Andrew C. McCreary, Arie T. Mulder, Guus J.M. van Scharrenburg, Herman H. van Stuivenberg, Theo J.J. Zethof, Barbara Zijta, Wouter I. Iwema Bakker,