Article ID Journal Published Year Pages File Type
2039957 Cell Reports 2015 11 Pages PDF
Abstract

•Genome and two transcriptomes of the bowhead whale, the longest-lived mammal•Bowhead-specific mutations in genes associated with cancer and aging (e.g., ERCC1)•Duplications in genes associated with DNA repair, cell cycle, and aging (e.g., PCNA)•Changes in genes related to thermoregulation (UCP1) and other bowhead traits

SummaryThe bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species.

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Life Sciences Agricultural and Biological Sciences Agricultural and Biological Sciences (General)
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