| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2042092 | Cell Reports | 2013 | 5 Pages |
SummaryThe generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.
Graphical AbstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Autologous iPSC-derived neural progenitors survive in the monkey brain for 6 months ► Grafted cells differentiate into neurons, astrocytes, and oligodendrocytes ► Autologous transplantation elicits minimal immune and glial response
